DOI: https://doi.org/10.36719/2789-6919/56/82-88
Comparison of Some Biochemical Indicators in Children With Rheumatism and Hereditary Collagenoses
Abstract
Rheumatism and hereditary collagenoses in children are complex hereditary and secondary diseases characterized mainly by connective tissue damage. These diseases cause disruption of metabolic processes in the body. Such processes are reflected in a number of biochemical indicators. Based on the analysis of many scientific literature sources, the review identifies the role of oxyproline, an important marker of collagen metabolism, glucosamine glycans, which are the main components of connective tissue, and inflammatory markers in rheumatism and hereditary collagenoses. The conducted analyses show that during these diseases, an increase in the level of oxyproline and glucosamine glycans in the blood is observed due to the breakdown of collagen. Especially in hereditary collagenoses, changes in these indicators are more persistent. While rheumatism is characterized by an increase in acute phase proteins, hereditary collagenosis is characterized by changes in indicators associated with metabolic disorders of connective tissue. However, the conducted analyses show that similar clinical symptoms occur in both diseases. It is precisely the differences in changes in biochemical indicators in these diseases that can ensure early diagnosis, prognosis and more accurate selection of treatment tactics.
Keywords: connective tissue, collagen, rheumatism, hereditary collagenosis, oxyproline, glucosamineglycan