DOI: https://doi.org/10.36719/2663-4619/127/251-257
Vusala Sardarly 
Azerbaijan State Agrarian University
Ganja, Azerbaijan
PhD of Biology
vusalasardar@hotmail.com
Ramil Mammadov
Azerbaijan State Agrarian University
Ganja, Azerbaijan
PhD of Agrarian Sciences
m.ramil201979@gmail.com
Ayten Aghayeva
Azerbaijan State Agrarian University
Ganja, Azerbaijan
aytan.agayeva@adau.edu.az
Turkan Babayeva
Azerbaijan State Agrarian University
Ganja, Azerbaijan
babayevaturk88@gmail.com
Rahile Farmanli
Azerbaijan State Agrarian University
Ganja, Azerbaijan
rahila.fermanli@adau.edu.az
Experimental Evaluation of an Alternative Treatment Method
for Necrobacteriosis in Lambs
Abstract
Necrobacteriosis remains an important infectious disease in livestock, leading to significant economic losses and severe systemic complications, particularly in young animals. The search for effective therapeutic approaches aimed at improving local antimicrobial activity and host immune response remains relevant.
The aim of this study was to evaluate the therapeutic efficacy of combined administration of naftalan oil, oxytetracycline, and the immunomodulatory preparation mixoferon in animals affected by necrobacteriosis.
The therapeutic effect of topical application of a naftalan oil–oxytetracycline mixture on lesions of the oral mucosa was investigated under experimental conditions. Clinical recovery dynamics and general condition of animals receiving combined therapy were assessed and compared with conventional treatment approaches.
Application of the naftalan oil–oxytetracycline combination was associated with improvement of local tissue condition and reduction of inflammatory manifestations, which contributed to accelerated clinical recovery. Additional administration of mixoferon was accompanied by improvement of nonspecific resistance indicators and a reduced tendency toward systemic spread of infection.
The obtained results indicate the potential effectiveness of complex therapy combining antimicrobial and immunomodulatory components in the treatment of necrobacteriosis. However, further studies using randomized controlled experimental designs, standardized outcome measures, and molecular diagnostic confirmation are required to validate these findings.
Keywords: necrobacteriosis, Fusobacterium necrophorum, naftalan oil, oxytetracycline, immunomodulation, veterinary therapy