https://doi.org/10.36719/3104-4700/2/10-14
Peri Huseynova
Nakhchivan State University
Doctoral student
https://orcid.org/0009-0002-7021-7806
perihuseynova@ndu.edu.az
Aliye Jafarli
Nakhchivan State University
https://orcid.org/0009-0001-3609-3873
ceferlialiye055@gmail.com
Aynur Aliyeva
Nakhchivan State University
https://orcid.org/0009-0003-0013-2206
aynuraliyeva05@icloud.com
Sakina Abdullayeva
Nakhchivan State University
https://orcid.org/0009-0000-4378-0148
abdlyvas17@gmail.com
Aytaj Alekberova
Nakhchivan State University
https://orcid.org/0009-0002-9970-7155
aytaclkbrli30@gmail.com
Schiff Bases in Biomedical Applications: A Review
Abstract
Schiff bases, a prominent class of organic compounds formed via condensation reactions between primary amines and carbonyl compounds, have attracted increasing attention in biomedical research. Their structural flexibility and chemical functionality enable a wide range of biological activities, positioning Schiff bases as promising candidates in antimicrobial strategies, drug delivery systems, diagnostic technologies, and biomaterial design. In recent studies, diverse Schiff base derivatives have demonstrated notable effectiveness against a broad spectrum of microbial strains, highlighting their potential as alternative or complementary agents in addressing antimicrobial resistance.
Beyond their direct biological activity, Schiff bases have been extensively investigated as functional components in advanced and targeted drug delivery systems. Their chemical adaptability supports the development of delivery platforms with controlled release behavior, improved bioavailability, and enhanced therapeutic efficiency. Such systems are particularly valuable in minimizing off-target effects and optimizing drug performance in complex biological environments. In parallel, the distinctive coordination and signaling properties of Schiff bases have facilitated their application in diagnostic and sensing technologies, where they have been employed in the detection and monitoring of biologically relevant species with high sensitivity and selectivity.
This narrative review critically discusses the biomedical applications of Schiff bases, with particular emphasis on their antimicrobial mechanisms, roles in targeted drug delivery, diagnostic sensing capabilities, and contributions to biomaterials for tissue engineering.
Keywords: schiff bases, antimicrobial activity, drug delivery, diagnostic sensors, biomaterials