DOI: https://doi.org/10.36719/2707-1146/43/9-19
Ilqar Hasanov
“Ozon” Medical Center, Ganja
Doctor of Science in Medicine
Aygun Aliyarbayova
Azerbaijan Medical University
Doctor of Philosophy in Medicine
EXPERIMENTAL STUDY OF CHANGES IN MORPHOLOGICAL PECULIARITIES
OF THE EOSINOPHILIC LEUKOCYTE IN THE LUNG UNDER THE INFLUENCE
OF THE MACROPHAGE MIGRATION INHIBITOR FACTOR
Abstract
The research investigated on observation of eosinophilic leukocytes in the lungs of white laboratory rats under the effect of a Macrophage migration inhibition factor (MIF) by light and electron microscopy. The object of the study was 60 white male rats subdivided into 3 groups: control, placebo (saline injection), and main (MIF injection). The eosinophilic leukocytes are detected by specific cytoplasmic eosinophilic granules and ultrastructurally visible distinctive osmiophilic granules. The subpopulations of indicated cells in the lungs were identified as "stromal-interstitial", within "BALT", "perivascular" and "bronchial". It was found that in the experiment, the administration of MIF induces the migration of eosinophilic leukocytes into the alveoli and respiratory tract. It is necessary to note that the introduction of MIF has a gradual effect on the quantification and functional activity of eosinophilic leukocytes in the lungs of laboratory white rats: an increase in the first 2-7 days and stabilization at a higher level in the next 15-30 days. At least two ways of the effect of MIF on eosinophilic leukocytes have been evaluated: 1) by direct reception of MIF and 2) by indirect mechanisms. After injection of MIF, eosinophilic leukocytes probably have a regulatory effect in various microzones of the lung. The obtained results show that research in this direction may be promising in modeling immunopathological lung diseases.
Keywords: eosinophilic leukocytes, MIF, morphology, lungs