DOI: https://doi.org/10.36719/2707-1146/61/27-30
Peri Huseynova
Nakhchivan State University
PhD student
https://orcid.org/0009-0002-7021-7806
perihuseynova@ndu.edu.az
Application Prospects of Hydrazone-Based Organic Ligands
Abstract
Hydrazone-based organic ligands represent a versatile class of compounds that have gained considerable attention in coordination chemistry and medicinal research due to their unique structural features and diverse functional properties. These ligands, characterized by the presence of an azomethine (–C=NNH–) group, can act as nitrogen–nitrogen donor systems, facilitating the formation of stable complexes with a wide range of metal ions. Recent studies have highlighted their potential in catalysis, metal sensing, and drug design, including antimicrobial, antifungal, and anticancer applications. The tunability of substituents on the hydrazone backbone allows for modulation of both electronic and steric properties, thereby influencing the stability, selectivity, and biological activity of the resulting complexes. This review systematically examines the recent advances in the synthesis, coordination behavior, and application prospects of hydrazone-based ligands. Key trends in ligand design, structure–activity relationships, and emerging therapeutic and industrial applications are discussed. This research provides a systematic review of the existing literature, revealing the promising possibilities of hydrazone ligands as functional molecules in organic synthesis and biomedicine.
Keywords: hydrazone, ligand, complexes, organic synthesis, catalysis, biological activity, medicine